This title slide is titled "Background & Incremental Impact on Conversion." The subtitle highlights "IQVIA 360Halo: Promotional Synergy and NRx Lifts from DTC & HCP."

Background & Incremental Impact on Conversion

IQVIA 360Halo: Promotional Synergy and NRx Lifts from DTC & HCP

Source: IQVIA 360Halo Analysis

This agenda slide outlines the presentation topics, starting with an IQVIA 360Halo Overview. It continues with Key Research Question, Background Details, Incremental Impacts, Statistical Significance, and Key Takeaways.

Agenda

1. IQVIA 360Halo Overview
2. Key Research Question
3. Background Details
4. Incremental Impacts
5. Statistical Significance
6. Key Takeaways

This slide evaluates DTC/HCP promotional synergy using a 1:1 patient-level test/control design to measure incremental NRx lifts. DTC only yields +0.3358% absolute lift (+59% relative), HCP only +0.4355% (+55%), and DTC+HCP overlap +0.0499% (+24%), all significant at >95% confidence.

Background & Incremental Impact on Conversion

• • Evaluates DTC/HCP synergy via 1:1 patient-level test/control design
• • Measures incremental NRx lift from combined promotional exposures
• • DTC Only: +0.3358% absolute lift (+59% relative)
• • HCP Only: +0.4355% absolute lift (+55% relative)
• • DTC + HCP Overlap: +0.0499% absolute lift (+24% relative)
• • All lifts significant at >95% confidence

Source: IQVIA 360Halo Analysis

The slide, titled "Background & Incremental Impact on Conversion," features a key question from the IQVIA 360Halo Analysis. It asks: "Are patients more likely to convert when exposed to DTC promotion and visit an HCP exposed to the HCP campaign?"

Background & Incremental Impact on Conversion

> Are patients more likely to convert when exposed to DTC promotion and visit an HCP exposed to the HCP campaign?

— Key Question, IQVIA 360Halo Analysis

Source: IQVIA 360Halo Analysis

The slide highlights incremental conversion lifts of +59% for DTC only (+0.3358% absolute), +55% for HCP only (+0.4355% absolute), and +24% for DTC + HCP (+0.0499% absolute). All lifts are statistically significant at >95% confidence level.

Background & Incremental Impact on Conversion

• +59%: DTC Only

+0.3358% absolute lift

• +55%: HCP Only

+0.4355% absolute lift

• +24%: DTC + HCP

+0.0499% absolute lift

• >95%: Confidence Level

All lifts significant Source: IQVIA 360Halo Analysis

IQVIA’s 360Halo Analysis evaluates DTC and HCP promotional synergy on patient conversion using a 1:1 patient-level test-control design, asking if dual exposure increases conversion likelihood. Incremental lifts are +0.3358% (DTC only, +59% relative), +0.4355% (HCP only, +55% relative), and +0.0499% (DTC+HCP overlap, +24% relative), all significant at >95% confidence.

Background & Incremental Impact on Conversion

**Background IQVIA’s 360Halo Analysis evaluates DTC & HCP promotional synergy using 1:1 patient-level test vs. control design to measure incremental NRx lift.

Key Question Are patients more likely to convert when exposed to DTC promotion and visit an HCP exposed to the HCP campaign?

Incremental Impact

• DTC Only: +0.3358% absolute lift (+59% relative)
• HCP Only: +0.4355% absolute lift (+55% relative)
• DTC + HCP Overlap: +0.0499% absolute lift (+24% relative)**

All Lifts Significant at >95% Confidence

Source: IQVIA 360Halo Analysis