This slide compares the pathophysiology workflow of pathogen-induced diarrhea (enterotoxins/invasion to dehydration) between pediatric and adult patients. Pediatrics shows amplified damage from immature guts, leading to profuse watery diarrhea and rapid severe dehydration, while adults exhibit resilient mucosa, slower progression, and milder symptoms.
Patho Workflow: P vs A
{ "headers": [ "Phase", "Pathophysiology", "Pediatric", "Adult" ], "rows": [ [ "Enterotoxins/Invasion", "Pathogen releases toxins or invades mucosa, disrupting fluid/electrolyte balance", "Immature gut barrier amplifies damage; higher receptor density for some toxins", "More resilient mucosa; often toxin-mediated without invasion" ], [ "Diarrhea Onset", "Hypersecretion and reduced absorption lead to watery diarrhea", "Profuse, frequent stools; rapid volume loss", "Less voluminous; inflammatory or secretory, but slower progression" ], [ "Dehydration", "Systemic fluid and electrolyte depletion", "Faster (hours-days); severe due to small reserves and high BSA/volume ratio", "Slower (days); milder, better compensatory mechanisms" ] ] }
Source: Enterotoxins/invasion ā Diarrhea. Kids: faster dehydration; Adults: slower.
Speaker Notes
Emphasize the accelerated dehydration risk in pediatrics due to higher body surface area to volume ratio and immature physiological reserves.