Generated from prompt:

Create a publicly accessible PowerPoint presentation titled 'RTT as a Systemic Disorder of Developmental Program Disruption', in English scientific style and a deep, visual tech theme (dark background with abstract neural network visuals). Slide 1: Cover Page - Title: RTT as a Systemic Disorder of Developmental Program Disruption - Subtitle: From Gene-Level Abnormalities to Developmental Program Failure - Author: (Leave blank) - Date: Auto-generated - Design: Dark background with neural network abstract visuals, light text, neon blue/purple highlights. Slide 2: RTT as a Systemic Disorder of Developmental Program Disruption - Key Sentence: RTT is not a single molecular defect, but a progressive imbalance of functional neural networks during development. - Page content: Rett Syndrome (neurodevelopmental disorder); Prefrontal Cortex (PFC) as a key functional area; Concept of developmental windows (early → mid → mature). - No methods or data figures. - Speaker Notes: RTT symptoms indicate failure of system-level maturation, not a broken pathway. Neurodevelopment is time-ordered. Disruption during key windows causes lasting imbalance. The question is not whether abnormalities exist, but when and how they are encoded into the brain. - Duration: ≈1.5 min. Slide 3: Reconstructing RTT Developmental Disruption via Single-Cell Modules - Key Sentence: Using single-cell omics, we elevate RTT abnormalities from the gene level to the developmental program level. - Page content: PFC single-nucleus transcriptome (multiple developmental stages); Stable developmental units (SEACells/meta-nuclei); Coordinated transcriptional modules; Abstract diagram (developmental timeline + module dynamics, no real data). - Speaker Notes: Single-cell data are complex; direct gene comparisons miss the developmental context. We focus on transcriptional programs co-varying during maturation. These modules act as biological subroutines driving functional maturation. In RTT, some programs deviate early; others lose coordination later — a dynamic accumulation of developmental disruption. - Duration: ≈2 min. Slide 4: From Developmental Modules to Circuits and Brain-Machine Integration - Key Sentence: Module disorganization manifests as circuit dysfunction; these modules themselves are potential regulatory targets. - Page content: Module ↔ cell type (excitatory/inhibitory/glial); Circuit maturation / E–I balance; Quantifiable state variables → intelligent regulation; Hierarchical diagram: module → cell → circuit → intervention. - Speaker Notes: Modules bridge molecular and circuit levels — potential entry points for therapeutic modulation and neural engineering. Ensure it is a deep, visual, tech-style design, publicly accessible, and downloadable as PPTX and PDF.