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Slide 1 - Key Biological Drivers
The slide outlines key biological drivers of reproductive issues, including insulin resistance that elevates androgens and impairs granulosa cell mitochondria, alongside chronic inflammation from cytokines like TNF-α and IL-6 that disrupts folliculogenesis and causes oxidative injury. It also covers oxidative stress damaging oocytes and meiotic structures, dyslipidemia leading to granulosa apoptosis and poor oocyte quality, and altered energy metabolism with low NAD⁺ and AMPK issues hindering mitochondrial biogenesis.
Key Biological Drivers
- Insulin Resistance: Excess insulin boosts androgens, impairs granulosa cell mitochondria.
- Chronic Inflammation: TNF-α, IL-6, CRP disrupt folliculogenesis and promote oxidative injury.
- Oxidative Stress: ROS damages oocytes, meiotic spindle, and mitochondrial potential.
- Dyslipidemia: Fatty acids induce granulosa apoptosis, reduce oocyte quality.
- Altered Energy Metabolism: Low NAD⁺, AMPK disruption hinders mitochondrial biogenesis.
Speaker Notes
Reproductive dysfunction is fundamentally a metabolic disorder mediated by inflammation, oxidative stress, and mitochondrial damage—not purely hormonal.
